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In the CNS, the loss of MdmX targeted alethality that was later than that seen with similar Mdm2 knockouts [104].

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There is, however, nodoubt that inadequate humidi?cation may leadto progressive airway dysfunction and systemiceffects, depending on the degree of underhu-midi?cation and coolness, the exposure time,and the underlying disease. RD are not limited by geographical orhistorical boundaries and global partnerships are rapidly expanding across the RDcommunity.
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