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Among the 27 EU Member States, only 8 Countries have alreadyadopted National Plans or strategies of different complexity and with different aims:France, Bulgaria, Czech Republic, Greece, Netherlands, Portugal, Slovenia, andSpain. Thereason for this interest is a fundamental tenet in pharma-cology and toxicology—that both beneficial and adverseresponses to compounds are related to the free concentra-tions of active compounds reaching target tissues, ratherthan the amount of compound at the site of absorption

Thereason for this interest is a fundamental tenet in pharma-cology and toxicology—that both beneficial and adverseresponses to compounds are related to the free concentra-tions of active compounds reaching target tissues, ratherthan the amount of compound at the site of absorption.

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Adverse lipids: total cholesterol = 260 mg/dL; HDL cholesterol = 35 mg/dL. ASCOT-LLA (2003): Anglo-Scandinavian cardiac outcomes trial–Lipid lowering arm

ASCOT-LLA (2003): Anglo-Scandinavian cardiac outcomes trial–Lipid lowering arm. Any deviation from an expected pattern shouldtrigger a search for additional spinal cord or peripheralnerve injuries.

For this purpose, classification according to pathogenesis,as first described by Waldvogel et al., is the best suited system [2, 3]. Overestimation of platelet aspirin resistancedetection by thrombelastograph platelet mapping and validation by conventionalaggregometry using arachidonic acid stimulation.

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