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Severe meta-bolic alkalosis leads to calcium binding to albumin causing hypocalcemia precipitatingmuscle weakness and decreased contractility. (2010a) High-caloriediet with moderate protein restriction prevents cachexia andameliorates oxidative stress, inflammation, and proteinuria inexperimental chronic kidney disease. It is coded for by thePRNP gene located on the short arm of chromosome 20(Oesch et al., 1985; Basler et al., 1986) and is a primar-ily membrane-bound protein on nerve and other cells(Figure 9.13). (1992)Haloperidol plasma levels and clinical response: a therapeuticwindow relationship.

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